The Multi-Institutional Hematopathology Interesting Case Conference (MHICC) is a monthly virtual CME meeting to provide a platform for oncologists, pathologists, and trainees from leading institutions across North America to collaboratively discuss complex and educational hematopathology cases. This interactive and case-based discussion forum offers a unique opportunity to engage with experts, review complex cases, and strengthen interdisciplinary collaboration in hematopathology.
Previous Cases
Date:Wednesday, October 22, 2025
Presenting Institution:NYU Grossman School of Medicine
Case 1 - A 3-year-old boy with one-week history of fever, fatigue, joint pain, refusal to move, pancytopenia and 44% blasts on CBC with demonstration of t(9;22) by FISH. Slides: 1-H&E, 2-Aspirate Smear. Case Pathology Slides | Presentation Slides
Case 2 - A 12-year-old boy with daily headaches, photophobia, ataxia, significant weight loss, peripheral blood eosinophilia, and diffuse leptomeningeal enhancement. Slides: 1-H&E, 2-CD3, 3-INI-1, 4-CD45. Case Pathology Slides | Presentation Slides
Case 3 - A 73-year-old woman with widespread lymphadenopathy, pancytopenia and B symptoms. Slides: 1-H&E, 2-CD3, 3-EBER-ISH, 4-Aspirate Smear. Case Pathology Slides | Presentation Slides
Case 4 - A 92-year-old woman with anemia and leukocytosis (62k). Slides: 1-PAX-5, 2-CyclinD-1, 3-H&E, 4-Aspirate Smear. Case Pathology Slides | Presentation Slides
Presenting Institution: University of Pennsylvania
Case 1: 69-year-old man who presented with abdominal pain exacerbated by eating, 30 lbs weight loss, and change in stool caliber. CT showed 9 x 9 cm small bowel mass.
Stains: H&E, CD3, CD20, PAX5, CD7
Case Pathology Slides | Presentation Slides
Case 2: 61-year-old woman with no significant past medical history presenting with isolated mildly PET avid left inguinal lymphadenopathy, 1 x 1 cm.
Stains: H&E, CD3, CD20, CD30
Case Pathology Slides | Presentation Slides
Case 3: 5-month-old male child presenting with focal seizures, fever, upper respiratory symptoms. Imaging showed 3.7 x 3.7 x 2.9 cm right frontoparietal brain mass.
Stains: H&E, CD45, CD117, P53
Case Pathology Slides | Presentation Slides
Case 4: 72-year-old man presenting with supraclavicular and submandibular lymphadenopathy, several months drenching night sweats, weight loss, and fatigue.
Stains: H&E, CD3, CD30, PAX5, CD45, Ki-67
Case Pathology Slides | Presentation Slides
Wednesday, August 27, 2025
Presenting Institution: University of Toronto
Case 1: A 49-year-old man with back pain and a lytic bone lesion in L1 vertebra.– Stains: 1- H&E, 2- CD20, 3- CD138. Case Pathology Slides | Presentation Slides
Case 2: 73-year-old man with left inguinal lymphadenopathy,– Stains: 1 – H&E, 2- CD2, 3- CD20. Case Pathology Slides | Presentation Slides
Case 3: 66-year-old man with right axillary lymph node enlargement – Stains: 1- H&E, 2- CD20, 3- CD3. Case Pathology Slides | Presentation Slides
Case 4: 44-year-old man with cervical lymphadenopathy and history of treated DLBCL,– Stains: 1- H&E, 2- Lysozyme. Case Pathology Slides | Presentation Slides
Date: Wednesday, June 25, 2025
Presenting Institution: Weill Cornell Medical College
Case 1: A 3-year-old boy presenting with stridor and found to have a 0.5 cm mass in the subglottis. Case Pathology Slides | Presentation Slides
Case 2: A 68-year-old female with a history of CLL/SLL who presents with worsening abdominal pain. PET-CT showed new FDG avid lymph nodes and multiple hepatic and splenic lesions. Case Pathology Slides | Presentation Slides
Case 3: A 61-year-old man with a history of bipolar disorder and alcohol abuse presents with declining mental status over the past month. MRI showed multiple intracerebral lesions. Case Pathology Slides | Presentation Slides
Date: Wednesday, May 28, 2025
Presenting Institution: Cleveland Clinic
Case Pathology Slides for Cases 1 - 4
Case 1: A 74-year-old male with history of squamous cell carcinoma of the tongue now presents with new tonsillar mass. Presentation Slides
Case 2: A 65-year-old female with history of Inflammatory bowel disease on treatment presents with incidental finding of left adrenal cyst (16 cm) noted on imaging. Presentation Slides
Case 3: An 82-year-old male with history of B-cell lymphoma from an outside hospital, now presenting with visible right neck lymphadenopathy and weight loss. Abbreviated ancillary studies provided for discussion around molecular findings. Presentation Slides
Case 4: A 45-year-old male with an isolated enlarged left groin lymph node. View Slides Presentation Slides
Date: Wednesday, April 23, 2025
Presenting Institution: MSKCC
Case 1: A 66F w/ history of breast carcinoma status post adjuvant chemotherapy and radiotherapy, presenting with neutropenia (ANC 0.7 K/uL), mild anemia (Hb 10.9 g/dL, MCV 95 fL, RDW 14%), and mild thrombocytopenia (Platelets 126 K/uL). Case Pathology Slides | Presentation Slides
Case 2: A 58F w/ a history of a myeloid neoplasm favored to be oligomonocytic chronic myelomonocytic leukemia presents with widespread lymphadenopathy. Case Pathology Slides | Presentation Slides
Case 3: A 63F with a history of breast carcinoma status post cytotoxic therapy presents with widespread lytic bone lesions, marked anemia (Hb 6.9 g/dL, MCV 98fL, RDW 22.1%) and thrombocytopenia (Platelets 64 K/uL). Case Pathology Slides | Presentation Slides
Date: Wednesday, March 19, 2025
Presenting Institution: Mount Sinai
Case 1: A 70-year-old man with a history of chronic lymphocytic leukemia (CLL) with
unexplained neutrophilia. Case Pathology Slides | Presentation Slides
Case 2: A 68-year-old man with violaceous-pink raised skin lesions. Case Pathology Slides | Presentation Slides
Case 3: A 65-year-old man with a history of multiple myeloma with worsening leukocytosis. Case Pathology Slides | Presentation Slides
Case 4: A 56-year-old woman with a history of AML with inversion 16 now with pancytopenia including severe neutropenia at ~220 days post-transplant. Case Pathology Slides | Presentation Slides
Date: February 26, 2025
Presenting Institution: FCCC
Case 1: Axillary lymph node biopsy in a 63-year-old woman with a history of squamous cell carcinoma (SCC) of the anal canal. A CT scan revealed diffuse adenopathy in the chest and abdomen. Case Pathology Slides | Presentation Slides
Case 2: Inguinal lymph node biopsy in an 81-year-old woman with newly detected lymphadenopathy. Case Pathology Slides | Presentation Slides
Case 3: Level 10L lymph node biopsy in an 80-year-old man with history of CLL, undergoing resection for newly diagnosed lung adenocarcinoma. Case Pathology Slides | Presentation Slides
Case 4: Biopsy of a large soft tissue mass at the first metatarsal-phalangeal joint in a 76-year-old man. Case Pathology Slides | Presentation Slides